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Since radial chromosomes have multiple centromeres, they can thwart normal chromosome segregation. The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Mol Cell 21 : —

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Some overhang Escort Chanda will be needed during c-NHEJ, but the nucleases involved are not yet known. Shelterin is highly compartmentalized such that different DDR pathways are activated at telomeres depending on which shelterin Escort Chanda is removed.

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First, CST is known to bind with high affinity to ds—ss junctions Bhattacharjee et al. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop Escort Chanda.

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Clin Cancer Res 25 : — Mol Cell 67 : — Escort Chanda Cell Biol 29 : Escort Chanda EMBO J 38 : e SSA is a dangerous repair pathway in genomes with many repetitive sequences, since deletions will be a frequent outcome. Two models for the Escort Chanda of the Rif1 axis. EMBO J 32 Escort Chanda Escort Chanda

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When the DSB is engaged in repair using the sister chromatid, 53BP1-driven mobility will not dislodge the DSB because of the counterforce of cohesion and Escort Chanda base pairing. Two Escort Chanda proteins that bind to wild-type but not mutant p Annu Rev Genet 52 : —

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