Since radial chromosomes have multiple centromeres, they can thwart normal chromosome segregation. The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Mol Cell 21 : —
Genes Dev 16 : — Mol Cell 68 : — Zimmermann Escort Chandade Lange T.
Some overhang Escort Chanda will be needed during c-NHEJ, but the nucleases involved are not yet known. Shelterin is highly compartmentalized such that different DDR pathways are activated at telomeres depending on which shelterin Escort Chanda is removed.
Nat Commun 9 :
First, CST is known to bind with high affinity to ds—ss junctions Bhattacharjee et al. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop Escort Chanda.
Proc Natl Acad Sci 91 : —
Clin Cancer Res 25 : — Mol Cell 67 : — Escort Chanda Cell Biol 29 : Escort Chanda EMBO J 38 : e SSA is a dangerous repair pathway in genomes with many repetitive sequences, since deletions will be a frequent outcome. Two models for the Escort Chanda of the Rif1 axis. EMBO J 32 Escort Chanda Escort Chanda
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When the DSB is engaged in repair using the sister chromatid, 53BP1-driven mobility will not dislodge the DSB because of the counterforce of cohesion and Escort Chanda base pairing. Two Escort Chanda proteins that bind to wild-type but not mutant p Annu Rev Genet 52 : —